Peripheral Blood Markers Associated with Immune-Related Adverse Effects in Patients Who Had Advanced Non-Small Cell Lung Cancer Treated with PD-1 Inhibitors

Wenhui Liu,1,2 Yiping Liu,1,2 Fang Ma,3 Bao Sun,1,2 Ying Wang,1,2 Jianquan Luo,1,2 Mouze Liu,1,2 Zhiying Luo1,2 1Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2Institute of Clinical Pharmacy, Central South University, Changsha, People’s Republic of China; 3Department

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Coupled sink and flow accumulation analyses with single flow direction and multiple flow direction algorithms

A static flood analysis (SFA) toolset is implemented with the Ice Cream Cone Dispensers purpose of performing simplified, event-based flood inundation modeling.The simulation process is divided into two steps: a topographic sink analysis of the terrain followed by flow accumulation (FA) of runoff volumes.Both procedures are coupled to account for s

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Has-miR-30c-1-3p inhibits macrophage autophagy and promotes Mycobacterium tuberculosis survival by targeting ATG4B and ATG9B

Abstract Autophagy is a widespread physiological process in the body, which also protects the host by degrading invading pathogens and harmful substances during pathological conditions.Nevertheless, Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis, has evolved strategies to subvert autophagy by modulating microRNA (miRNA) expre

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